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Contraindicated (one)pentobarbital will lessen the extent or effect of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can lessen panobinostat concentrations by ~70% and bring on pr